Drug Screening

Obatala® offers in vitro studies in 2D and 3D systems. Obatala’s 3D cell culture system, ObaCell®, consists of setting up the systems with our proprietary human-derived hydrogel, ObaGel®. Customers can request in vitro studies be performed solely in 2D or 3D culture or in both of our cell culture systems. Our cell culture services include cell isolation and expansion in 2D or 3D systems from tissues that are internally available at Obatala (human adipose, bone marrow, bone, or placenta) or from human- or animal-derived tissues provided by the customer. In addition to the isolation and expansion in our different cell culture systems, Obatala can perform lineage specific differentiation of cells, staining of cells, and quantification of the staining if desired.

Fat-ON-A-CHIP Model

ObaCell® is a great tool for disease modeling and drug screening. We can provide data in various areas depending on your interests.

Proteomics

We can measure changes in proteins expressed as well as those secreted.

Genomics

If a biomarker is expressed at a genomic level and isn’t abundantly expressed in the conditioned medium, we can digest our ObaCell® Fat-on-a-Chip constructs and analyze gene expression.

Adipokine secretion

We can look at any adipokine of interest and any other markers of safety that you are interested in.

Functionality

We can measure endpoints such as glucose uptake and lipolysis at various timepoints giving an indicator of adipose tissue functionality.

Chip Services

ObaCell® was created as a tool for disease modeling and drug screening; moreover, it's a versatile plug-and-play system capable of seamless integration with other organ-on-a-chip models, offering boundless potential for transformative research and innovation ith either 2D or 3D models.

Our Fat-on-a-chip- and Obesity-on-a-Chip services provide ready to use models for drug research, allowing for all the user's need to be met.

ASC Fat-On-A-Chip service
SVF Fat-on-a-chip service
Obesity-on a chip service

Our ObaCell® Fat-on-a-Chip services include a ready to use organoid model cultured in a 96-ell plate format of either SVF or ASC cells. Customize your model by choosing a unique cell donor(s) from our diverse inventory that best represents the prevalent population modeled in your study. Choose up to 4 cell donors per plate. A 3-week lead time is needed to initiate culture in our lab before completing endpoint services.

Model Highlights

  • In-vitro self-assembled organoids
  • Physiologically and functionally relevant human-derived adipose model
  • Matrix protein profile supports cell growth, motility, and vascular response

Applications

  • Drug Screening
  • Biomedical Device Evaluation

ObaCell® Obesity-on-a-Chip, is a next-gen advancement for researchers seeking to redefine drug discovery in metabolic diseases. This innovative platform offers an unparalleled opportunity to emulate the intricate physiology of an obese individual in a fraction of the time, accelerating the pace of research and enabling swift identification of promising drug candidates.

Product Uses

  • Optimized Drug Discovery: ObaCell® Obesity-on-a-Chip facilitates efficient screening of potential therapeutics, allowing researchers to make informed decisions rapidly and effectively, save resources, and expedite time to market.

Key Features

  • 3D Cellular System: Human adipose-derived stromal/stem cells differentiated into adipocytes with large lipid droplets, offering a metabolically active adipose model responsive to GLP-1 drugs.
  • Adipocyte Hypertrophy Simulation: Increased lipid size mimics adipocyte hypertrophy, providing a more accurate representation of obese physiology. Model also simulates fasting/feeding.
  • Enhanced Metabolic Function: Replicates human adipose tissue metabolism, facilitating precise drug screening and research.
  • Dynamic Compatibility: Highly compatible with functional assays and dynamic outputs, ensuring reliable and reproducible experimental results.
  • Customizable: Allows for selection of unique cell donors from our diverse inventory to match the prevalent population modeled in your study

Endpoint Services

  • Lipid Droplet Quantification

  • Metabolic Activity

  • Cell Viability Staining

  • Secretome Analysis

  • Cytokine Profiles

  • RNA and Protein Expression

  • Lipolysis

  • Glucose Uptake

  • Microscopy

    • Bright-field

    • Fluorescent

    • Confocal

    • High-Throughput

Service Inquiry

Please fill out and submit the form below with details regarding your service request for this model. Our Sales team will return your response asap. If you incur any issues with the form, please email orders@obatalasciences.com

SUBSCRIBE

Sign up with your email address to receive our monthly newsletter.