Optimize your science with ObaGel®
Obatala Sciences™ offers the first commercially available human derived 3D culture scaffold, ObaGel®. ObaGel® is an innovative product designed to overcome the translational barrier between animal models and clinical response.
ObaGel® enables researchers to use all human derived products in their research and better replicate in vivo response in vitro.
Place your order online or contact our dedicated research team to identify the appropriate service contract. We work collaboratively with our clients to ensure the highest level of scientific rigor and customer satisfaction.
For 3D and 2D culture work using ObaGel®, we also recommend using ObaVate™, which is available in a bundle with ObaGel.
Tell us about your research. Our dedicated research team will help you identify the appropriate service or product.
When cultured in ObaGel®, Cells remodel the polymerized matrix and form mature fat cells with spaces that contain lipid droplets. These images are cryo-scanning electron microscopy (cryo-SEM) images of ObaGel® alone (left) and seeded with stromal vascular fraction cells (right).
Better - ONLY Human-Derived commercial matrix
Faster - Enables faster indicators of human response
Hydrogel
Source
Integration into Workflow
Cell Recovery
Visualization
Spheroid Culture
ObaGel™
Human derived
Easily manipulated
Cell recovery consistently above 90% in 3D system
Highly transparent, easily imaged
Self-assembly, no additional methods
Industry Competitors
Animal derived
Overly complex methods required
Inconsistent, <90%
Often times difficult to characterize structure, problems with opacity and autofluorescence
Requires culturing to create spheroid
ObaGel® Companion Products
ObaVate™ is the activation agent for ObaGel™. It allows for fine tuning of ObaGel® to meet specific experimental criteria, i.e. 3D or 2D culture.
ObaZolve™ enables the recovery of cells cultured on ObaGel®. We have seen over 90% recovery after a 21 day culture!
ObaFlow™ allows for Flow Cytometry analysis of cells that have been cultured in ObaGel™ in 3D culture.
Our protocols have more information about how to use these products.
Publications
2020
- Human Adipose Derived Cells in Two- And Three-Dimensional Cultures: Functional Validation of an In Vitro Fat Construct. Stem Cells Int. 2020 Jun 10
- Fat-on-a-Chip Models for Research and Discovery in Obesity and Its Metabolic Co-Morbidities Tissue Eng Part B Rev. 2020 Mar 26.
2019
- Human Adipose-Derived Hydrogel Characterization Based on In Vitro ASC Biocompatibility and Differentiation. Stem Cells Int. 2019 Dec 27
- Decellularized Adipose Tissue Hydrogel Promotes Bone Regeneration in Critical-Sized Mouse Femoral Defect Model. Front. Bioeng. Biotechnol., 06 September 2019
- Decellularized Adipose Tissue: Biochemical Composition, in vivo Analysis and Potential Clinical Applications. Cell Biology and Translational Medicine, Volume 6 pp 57-70
2018
- A Novel, Sterilized Microvascular Tissue Product Improves Healing in a Murine Pressure Ulcer Model. Plastic and Reconstructive Surgery – Global Open. 6(11):e2010, November 2018. Gender and age-related cell compositional differences in C57BL/6 murine adipose tissue stromal vascular fraction. Adipocyte vol. 7 pg. 183-189
- Comparative proteomic analyses of human adipose extracellular matrices decellularized using alternative procedures. Journal of Biomedical Materials Research vol. 106 pg. 2481-2493
2017
- Sandwiched White Adipose Tissue: A Microphysiological System of Primary Human Adipose Tissue. Tissue Engineering vol. 24 pg. 135-145
2016
- Serially Transplanted Nonpericytic CD146(-) Adipose Stromal/Stem Cells in Silk Bioscaffolds Regenerate Adipose Tissue In Vivo. Stem Cells vol. 34 pg. 1097-1111
2014
- Burned to the bone. Science Translational Medicine vol.6